Durante el proceso de reprogramación ‘in vivo’, los telómeros de las de los telómeros en la regeneración de los tejidos, el envejecimiento y. Feb 23, Telomerós, Envejecimiento y Prevención Dr. Arturo Fernández- Cruz .. Envejecimiento celular – Estrés oxidativo: Integridad del telómero. Telómeros más cortos están relacionados con un mayor envejecimiento celular. Diferentes estudios han demostrado que los telómeros.

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Synthesis of the leading strand, catalyzed by DNA polymerase III, occurs by sequential addition of deoxyribonucleotides in the same direction as movement of the growing fork.

Early in apoptosis, dense chromosome condensation occurs along the nuclear periphery. The cell body also shrinks although most organelles remain intact. Later both the nucleus and cytoplasm fragment, forming apoptotic bodies. These are phagocytosed by surrounding cells. Clearly visible in the latter are dense spheres of compacted chromatin as the nucleus begins to fragment. Kuby,Immunology, 3d ed. Part b from M. Three general types of proteins are critical in this conserved pathway.


Regulators either promote or suppress apoptosis; the two regulators shown here, CED-9 and Bcl-2, both function to suppress apoptosis in the presence of trophic factors.


Adapters interact with both regulators and effectors; in the absence of trophic factors, they promote activation of effectors. A family of cysteine proteases serve as effector proteins; their activation leads to degradation of various intracellular substrates and eventually cell death. Korsemeyer,Cell The details of these pathways in any given cell type are not yet known.

Bad, a soluble pro-apoptotic protein, binds to the anti-apoptotic proteins Bcl-2 and Bcl-xl, which are inserted into the mitochondrial envfjecimiento. Bad binding prevents the anti-apoptotic proteins from interacting with Bax, a membrane-bound pro-apoptotic protein.


As a consequence, Bax forms homo-oligomeric channels in the membrane that mediate ion flux. Through an as-yet unknown mechanism, this leads to the release of cytochrome c from the space between the inner and outer mitochondrial membrane. Cytochrome c then binds to the adapter protein Apaf-1, which in turn promotes a caspase cascade leading to cell death.

In some cells, binding of trophic factors stimulates PI-3 kinase activity, leading to activation of the downstream kinase Akt, which phosphorylates Bad.


Phosphorylated Bad then forms a complex with the protein. Henderson,Neuron Cancer and the Cell Cycle: An overview Ken Wu.

Disclaimer This tutorial is a simple and conceptual guide to the cancer module and the cell cycle If there. Caspases in pmediated Neuronal Death Pathway.

Involvement of Histone H1. Cell Death Know the terminology: Enfejecimiento mechanisms of apoptosis in mammalian. ApoptosisNecrosis Apoptosis is a form of programmed cell death Apoptosis is responsible for the formation of digits in the developing mouse paw.

My presentations Profile Feedback Log out. Auth with social network: Registration Forgot your password? The Birth and Death of Cells. Developmental processes during which apoptosis can occur. OK What is apoptosis?? Apoptosis is a morphological term. About project SlidePlayer Terms of Service.

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