HYPERVARIABLE MINISATELLITE REGIONS IN HUMAN DNA PDF

The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–base pair ‘core’ sequence similar to the. Genetic analysis is now simplified by the availability of probes for hypervariable regions of human DNA showing multiallelic variation and correspondingly. A minisatellite is a tract of repetitive DNA in which certain DNA motifs are typically repeated times. Minisatellites occur at more than 1, locations in the human genome and In humans, 90% of minisatellites are found at the sub- telomeric region of “Hypervariable ‘minisatellite’ regions in human DNA”. Nature.

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Please add a reason or a talk parameter to this template to explain the issue with the article. You could not be signed in. Sign in via your Institution Sign in. Don’t have an account? These variant repeats are tandemly intermingled. Sign In or Create an Account. Retrieved from ” https: Sequences flanking the repeat arrays of human minlsatellites: Please check for further notifications by email.

Jeffreys; Sequences flanking the repeat arrays of human minlsatellites: Studies have shown [ citation needed ] that the evolutionary fate of minisatellites tends towards an equilibrium distribution in the size of alleles, until mutations in the flanking DNA affect the recombinational activity of a minisatellite by suppressing DNA instability.

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We present DNA sequences flanking cloned hypervariable human minisatellites. Citing articles via Web of Science Repeat turnover therefore appears to be controlled by recombinational activity in DNA that flanks the repeat array and results in a polarity of mutation.

Hypervariable ‘minisatellite’ regions in human DNA.

WikiProject Genetics may be able to help recruit an expert. H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing. A minisatellite is a tract of repetitive DNA in which certain DNA motifs ranging in length from 10—60 base pairs are typically repeated times. Oxford Regionw Press is a department of the University of Oxford. When shorter 10—bp tandem repeats were later identified, they came to be known as minisatellites.

It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide. There might be a discussion about this on the talk page. I agree to the terms and conditions. While other genomes mouse, rat and pig contain minisatellite-like sequences, none was found to be hypermutable. Abstract We present DNA sequences flanking cloned hypervariable human minisatellites.

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Hypervariable ‘minisatellite’ regions in human DNA.

It has been rehions that minisatellite sequences encourage chromosomes to swap DNA. Thank you for submitting a comment on this article. Minisatellites consist of repetitive, generally GC -rich, [ citation needed ] motifs that range in length from 10 to over base pairs.

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Add comment Close comment form modal. By using this site, you agree to the Terms of Use and Privacy Policy. Minisatellites are prominent in the centromeres and telomeres of chromosomes, the latter protecting the chromosomes from damage. This article has multiple issues.

This article is about the DNA sequence. Since all hypermutable minisatellites contain ena variantsthey provide extremely informative systems for analyzing the complex turnover processes that occur at this class of tandem repeat.

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Receive exclusive offers and updates from Oxford Academic. Hypervariable minisatellites have core units 9—64 bp long and are found mainly at the centromeric da. From Wikipedia, the free encyclopedia.

Dynamic evolution of megasatellites in yeasts. This article is also available for rental through DeepDyve.